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CML patient with HIV+ status

  • Jeff Lipton
  • Jeff Lipton's Avatar Topic Author
10 years 7 months ago #781 by Jeff Lipton
Replied by Jeff Lipton on topic Re: CML patient with HIV+ status
Good feedback
Thanks
Will start with imatinib and go from there.
  • Hemant Malhotra
  • Hemant Malhotra's Avatar Topic Author
10 years 7 months ago #782 by Hemant Malhotra
Replied by Hemant Malhotra on topic Re: CML patient with HIV+ status
Out of a total of about 300 plus patients of CML on treatment at our center, 2 are HIV positive and are on HART.
Both are on Imatinib 400 mg/day and tolerating the well.
No experience with the 2nd Gen TKIs.
The problem for the patient is taking too many drugs per day leading to compliance issues.
Also, anemia, because of the ART or Imatinib, is an issue in these patients.
No other issues with toxicities or responses.
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10 years 7 months ago #783 by serenamerante
I have 2 HIV+CML and 1 HES FIP1 positive patients on Imatinib. Imatinib is well tolerated and all of these are in complete cytogenetic response. There are also some published evidence about a synergistic effect of HART and IM.
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