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Science & Education
CML Science News
Clinical reality in CML is in constant change. Thanks to the hard work and progress of clinicians and researchers worldwide, interesting updates on CML science, diagnostics, treatment and care are regularly presented at international meetings and published in leading peer-reviewed journals.
This section provides you with a selection of scientific publications on CML, relevant news from scientific meetings and expert opinions from leaders in the field. You will also find links to active CML clinical trials.
Hepatitis B and CML - Participate in the survey of practice
Please share your experiences
Guidance from hepatologists suggests patients with CML on TKI therapy and HBV should receive antivirals and that viral load should be monitored. However, there are mixed messages in the literature and guidelines and clear practical guidance on screening and monitoring for HBV in these patients is lacking. Most hematology centres have very few CML patients who are Hepatitis B positive and therefore again, experience and practical guidance for HBV reactivation for people also being treated for CML is limited.
On the initiative of Professor Dragana Milojkovic (Imperial College London, UK), the iCMLf has formed a HBV and CML Working Group*. This group will collect and collate global experiences of physicians treating CML and HBV with the aim of developing recommendations on monitoring and treatment of HBV for patients with CML.
The iCMLf Hepatitis B virus (HBV) Screening and Management Survey is now open.
CML publications
Please find below a selection of interesting articles on CML from peer-reviewed journals. Recent publications include:
Clinical CML papers
- Asciminib in newly diagnosed chronic myeloid leukemia. Reply.
Hochhaus A et al. N Engl J Med, December 2024 - Asciminib add-on to imatinib demonstrates sustained high rates of ongoing therapy and deep molecular responses with prolonged follow-up in the ASC4MORE study
Hughes TP et al. J Hematol Oncol, December 2024 – open access publication - The effect of body mass index on the safety of bosutinib in patients with chronic myeloid leukemia: A post hoc pooled data analysis
Isfort S et al. Leuk Res, December 2024 - Advanced-stage chronic myeloid leukemia: Options for difficult treatment situations – Review
Atallah E and Deininger M. Drugs, December 2024 (epub ahead of print) - Novel treatment strategies for chronic myeloid leukemia
Cruz-Rodriguez N and Deininger M. Blood, December 2024 (epub ahead of print) - Mutation of epigenetic regulators at diagnosis is an independent predictor of tyrosine kinase inhibitor treatment failure in chronic myeloid leukemia: A Report from the RESIDIAG Study
Guerineau H et al. Am J Hematol, December 2024 (epub ahead of print) – open access publication - Safety and efficacy of flumatinib as later-line therapy in patients with chronic myeloid leukemia
Yang Y et al. Haematologica, December 2024 – open access publication - Understanding and overcoming resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) - Review
Lagana A. at al. Expert Rev Hematol, December 2024 (epub ahead of print) - Temporal effect of imatinib adherence on time to remission in chronic myeloid leukemia patients
Clark SE et al. J Oncol Pharm Pract, December 2024 - Is there really an accelerated phase of chronic myeloid leukemia at presentation?
Yang S et al. Leukemia, December 2024 (epub ahead of print) – open access publication
Scientific CML papers
- Correlation analysis of bone marrow microvessel density and miRNA expression on drug resistance in patients with chronic myeloid leukemia after tyrosine kinase inhibitor treatment
Guo YG et al. Hematology, December 2024 – open access publication - BCR::ABL1-induced mitochondrial morphological alterations as a potential clinical biomarker in chronic myeloid leukemia
Suzuki K et al. Cancer Si, December 2024 – open access publication
CML Congress Materials
European Hematology Association (EHA) 2024 Hybrid Congress
13-16 June, 2024 - Madrid
Click here to access the EHA Library and find oral presentations, e-Posters and abstracts on CML:
- Oral presentations - biology & translational research
- Oral presentations - clinical
- e-Posters - biology & translational research
- e-Posters - clinical
- Poster presentations - biology & translational research
- Poster presentations - clinical
- For publication only - biology & translational research
- For publication only - clinical
Ongoing clinical trials on CML
Search here for CML clinical trials:
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