Clinical Case Discussion Forum

Subscribe to the Clinical Case Discussion Forum

× To share and enhance best practice management of CML, experts and interested clinicians can discuss difficult or interesting CML cases here. Physicians submit a brief history of the patient and the case for discussion (no more than 200 words) by posting it in this forum ("New Discussion" button below). Please include the country of origin.

Each clinical case will be forwarded to the expert clinical panel for a brief independent response. Consideration should be given to patient confidentiality. Details that are not critical to the case can be changed to preserve anonymity. Please consider including your email with the case. This will not be posted on the website, but is useful should further details be requested by the moderator.

As a full clinical history is necessary for accurate comment, cases and comments on the Forum are ONLY ACCEPTED FROM PHYSICIANS. If individual patients have a specific question we encourage them to contact their healthcare provider. General questions can be emailed to info@cml-foundation.org.

DISCLAIMER: The iCMLf does not recommend or endorse any specific tests, physicians, products, procedures, or opinions, and disclaims any representation, warranty, or guaranty as to the same. Reliance on any information provided in this Forum is solely at your own risk.

CMR survival rate/cure

Start
Prev
1
Next
End

Dr Sharma
Topic Author

11 years 4 months ago #507 by Dr Sharma

CMR survival rate/cure was created by Dr Sharma

After achieving cmr at 2yrs 3 mths what is the rate of overall
survival and is there a chance of cure?
dr sharma

Guiseppe Saglio
Topic Author

11 years 4 months ago #509 by Guiseppe Saglio

Replied by Guiseppe Saglio on topic Re: CMR survival rate/cure

According to the ILTE (Imatinib Long Term Evaluation) study, CML patients who under imatinib therapy have achieved complete cytogenetic remission and are still in CCyR after to years of therapy, have a life expectancy similar to the o control population without leukemia. If this patients were also able to achieve CMR and to remain in CMR for at least 2 years, they have also the possibility to try to discontinue the treatment with an expected rate of successful discontinuation of approximately 40%. Longer the period of TKI therapy and of assessed CMR, however, higher the probability of successful discontinuation. Several clinical trials are presently ongoing to establish the optimal conditions allowing treatment discontinuation and it is recommended to enter one of such protocols in the attempt to try to discontinue the therapy or at least to do it under strict control of the hematologist of reference.

John Goldman
Topic Author

11 years 4 months ago #513 by John Goldman

Replied by John Goldman on topic Re: CMR survival rate/cure

I agree entirely with Dr Saglio and have little to add. I would simply mention that patients who achieve and maintain a complete molecular response do seem to have a survival comparable to that of normal people provided that they continue to take the TKI. Continued adherence is almost certainly very important in most cases, (though possibly not in all).

Furthermore the definition of cure is not straightforward. For example, are people who sustain an infection with herpes zoster (and retain the virus in their body, yet have a normal life span) ever truly cured?

Start
Prev
1
Next
End

Moderators: Nicola, arlene

Copyright © 2023 All Rights Reserved. The iCMLf is registered as charity no. 1132984 in England and Wales
Registered Address: International CML Foundation - 20 Eversley Road - Bexhill-On-Sea, East Sussex, TN40 1HE - UK