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Read Professor Hughes' summaries of key CML publications
This series of paper summaries is an extension of Professor Tim Hughes' 'CML publications of the month' news service.
These summaries, selected and curated by Professor Hughes, will be compiled and provided every three months, offering a comprehensive overview of key CML papers. This approach ensures that clinicians, researchers, and healthcare professionals stay up-to-date with important pivotal studies and emerging trends in CML research.
CML paper summary #2 - October 2024: Point-of-care BCR::ABL1 transcript monitoring using capillary dried blood in CML patients (Sala-Torra O et al. Leukemia, June 2024)
Link to full paper (Leukemia (2024) 38:1822–1824)
This study published in Leukemia explores a novel method for monitoring BCR::ABL1 transcripts in CML patients using a point-of-care dried capillary blood (DCB) collection system. The primary goal was to assess the correlation between BCR::ABL1 transcript levels in DCB and standard venous blood samples.
CML paper summary #1 - July 2024: Asciminib in newly diagnosed CML (Hochhaus A et al. NEJM, May 2024)
Link to full paper (ClinicalTrials.gov no. NCT04971226)
The ASC4FIRST study published in the New England Journal of medicine serves as the first example in this series. This phase 3 trial investigates the efficacy and safety of asciminib compared to established tyrosine kinase inhibitors (TKIs) in the first-line treatment of chronic-phase CML.
