I agree with Franck, although the dose needs to be worked out. I would start her on Pegasys at 180mcg weekly and titrate the dose interval based on counts. If Pegasys is not available then use regualar IFN again titrating the dose and/or interval to keep the counts appropriate. Monitor the molecular level over the next 6-9 months and then if stable, she should try to get pregnant. There is some suggestion that eggs harvested while women are on imatinib may not be the best for IVF and early in vitro embryo death has been noted. Interferon is quite safe in pregnancy and I have had 2-3 patients on interferon undergone fertility therapy that resulted in successful pregnancy. This can include stimulation if necessary while on interferon. If the molecular response is lost during the 6-month observation period, then resume the TKI after harvesting eggs. I daresay the likelihood of this woman being able to stop TKI at a later date will be quite small if she could not stop and switch to interferon successfully at this stage.