Hi,
this is a question about a 17 year old boy now day +239 post allo BMT for TKI resistant CML .
Here are post BMT results for BCR-ABL t(9;22) RT-PCR:
+ 1 month: PB negative, BM 0.0072
+2 months: PB N/A, BM 0.0044
+3 months: PB negative, BM 0.0025
+5 months: PB N/A, BM <0.002
+8 months: PB N/A, BM 0.0042
When would you repeat another BM exam for confirmation of the slightly higher BCR-ABL level ?
How worrisome is the positive signal in bone marrow at this timepoint after BMT and at what BCR-ABL level would you consider TKI treatment meant or DLI ?
Our patients most recent STR chimerism from BM was 99.77 %.
Many thanks,
Uli