As part of our monthly news service we would like to make you aware of the CML publications of the month. From the many papers published every month Professor Timothy Hughes has selected topical, interesting papers for your perusal that also include an interesting publication on pediatric CML.

Read Professor Hughes' CML publications of the month: November 2024

Clinical CML papers

• Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib and asciminib: A phase 1b randomized clinical trial
  Jabbour E et al. JAMA Oncol, November 2024 (epub ahead of print)
• Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND Study
  Yeung DT et al. Blood, November 2024
• Long-term outcomes of tyrosine kinase inhibitors in chronic myeloid leukemia
  Guilhot F and Hehlmann R. Blood, November 2024 (epub ahead of print)
• Dose modifications in the management of chronic phase chronic myeloid leukemia: Who, what, and when - Review
  Oehler VG et al. J Natl. Compr Canc Netw, November 2024 – open access publication
• Loss in overall and quality-adjusted life expectancy for patients with chronic-phase chronic myeloid leukemia
  Chen EY et al. Eur J Haematol, November 2024 (epub ahead of print) – open access publication
• Real-world toxicity and efficacy of asciminib in heavily pretreated patients with chronic myeloid leukemia
  Ishii Y et al. Int J Haematol, November 2024 (epub ahead of print)
• Clinical outcomes in patients in any phase of CML treated with ponatinib in France-Data from the TOPASE Observational Study
  Huguet F et al. Br J Haematol, November 2024 (epub ahead of print) – open access publication
• Comparing de novo chronic myeloid leukemia in blastic phase with Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation
  Okada Y et al. Cancer, November 2024 (epub ahead of print)
• Myelofibrosis predicts deep molecular response 4.5 in chronic myeloid leukemia patients initially treated with imatinib: An extensive, multicentred and retrospective study to develop a prognostic model
  Zeng T et al. Clin Trans Med, November 2024 – open access publication
• Decitabine, venetoclax, and ponatinib for advanced phase chronic myeloid leukemia and Philadelphia chromosome-positive acute myeloid leukemia:
  A Single arm, single centre phase 2 trial
  Short NJ et al. Lancet Haematol, November 2024

Scientific CML papers

• Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response
  Warfvinge R et al. eLife, November 2024 – open access publication
• Immune checkpoints PD1/PDL1, TIM3/GAL9 and key immune mediators landscape reveal differential expression dynamics on imatinib response in chronic myeloid leukemia
  Toloza MY et al. Ann Hematol, November 2024 (epub ahead of print)
• A novel next generation sequencing assay for the identification of BCR::ABL1 transcript type and accurate and sensitive detection of TKI-resistant mutations
  Yan Z et al. J Appl Lab Med, November 2024
• The CML experience to elucidate the role of innate T-cells as effectors in the control of residual cancer cells and as potential targets for cancer therapy
  Decroos A. et al. Front Immunol, November 2024 – open access publication

Pediatric papers

• Treatment-free remissions in children with chronic myeloid leukemia (CML):
  A prospective study from the Tata Memorial Hospital (TMA) Pediatric CML (pCML) cohort
  Roy Moulik N et al. Am J Hematol, November 2024 (epub ahead of print) – open access publication

LMIC CML papers

• Health-related quality of life and financial burden in Ethiopian patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors: A cross sectional study
  Tadesse F et al. JCO Global Oncol, November 2024 – open access publication
• Prognostic Significance of Regulatory T-Cells and PD-1 + CD8 T-Cells in Chronic Myeloid Leukemia Patients Treated with Generic Imatinib
  Saj F et al. Indian J Hematol Blood Transfus. October 2024
• Maternal and Foetal Outcomes of Newly Diagnosed Chronic Myeloid Leukemia During Pregnancy and its Long-Term Impact
  Bhattacharjee U et al. Indian J Hematol Blood Transfus., October 2024

Read Professor Hughes' summaries of key CML publications

This series of paper summaries is an extension of Professor Tim Hughes' 'CML publications of the month' news service.
These summaries, selected and curated by Professor Hughes, will be compiled and provided every three months, offering a comprehensive overview of key CML papers. This approach ensures that clinicians, researchers, and healthcare professionals stay up-to-date with important pivotal studies and emerging trends in CML research.

CML paper summary #2  - October 2024: Point-of-care BCR::ABL1 transcript monitoring using capillary dried blood in CML patients (Sala-Torra O et al. Leukemia, June 2024)
Link to full paper (Leukemia (2024) 38:1822–1824)

This study published in Leukemia explores a novel method for monitoring BCR::ABL1 transcripts in CML patients using a point-of-care dried capillary blood (DCB) collection system. The primary goal was to assess the correlation between BCR::ABL1 transcript levels in DCB and standard venous blood samples.

View the paper summary here

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