CML publications

Please find below a selection of interesting articles on CML from peer-reviewed journals. Recent publications include:

Clinical CML papers

Ophthalmic findings leading to diagnose chronic myeloid leukemia: A multimodal image case report
Hoyos A et al. Eur J Ophthalmol, February 2025 (epub ahead of print)
Asciminib in the treatment of chronic myeloid leukemia chronic phase – Review
Costa A et al. Future Oncol, February 2025 (epub ahead of print)
A nomogram for predicting T315I-free survival in chronic-phase chronic myeloid leukemia patients: A multicentre retrospective study
Hu SW et al. Sci Rep, February 2025 – open access publication
Introduction to a series of reflections on a quarter century of TKIs for CML
Druker BJ. Blood, February 2025 – open access publication
Vodobatinib for patients with Philadelphia chromosome-positive chronic myeloid leukemia resistant or intolerant to multiple lines of previous therapy: an open-label, multicentre, phase 1 / 2 trial
Cortes JE et al. Lancet Haematol, February 2025 (epub ahead of print)
Blast-phase chronic myeloid leukemia presenting as early T-cell precursor acute lymphoblastic leukemia
Shuyu E et al. Am J Clin Pathol, February 2025
Inflammatory/immune adverse events in chronic myeloid leukemia patients during treatment with Bosutinib
Agostani E et al. Cancer Med, February 2025 – open access publication
Total psoriasis regression in a patient with chronic myeloid leukemia treated using Nilotinib
Horňák T et al. Ann Hematol, February 2025 (epub ahead of print) – open access publication
Fibrosis and treatment-free remission in chronic myeloid leukemia
Brailovski E et al. Br J Haematol, February 2025 (epub ahead of print)
BCR::ABL1 deep molecular response quantification and transcript type identification in chronic myeloid leukemia using a US Food and Drug Administration-approved droplet-based PCR assay
Kockerols C et al. J Mol Diagn, February 2025 – open access publication
Stopping bosutinib reverses bosutinib-induced elevation of serum creatinine in patients with chronic myeloid leukemia
Abumiya M et al. Int J Hematol, February 2025 (epub ahead of print) – open access publication
Treatment-free remission outcomes in BCR::ABL1 digital PCR selected clinical cohort of chronic myeloid leukemia patients
Kockerols C et al. Eur J Haematol, February 2025 (epub ahead of print) – open access publication
Challenges determining the best target duration of deep molecular response after which to attempt achieving therapy-free remission in chronic myeloid leukemia
Gong X et al. Leukemia, February 2025 (epub ahead of print) – open access publication
Loss in overall and quality-adjusted life expectancy for patients with chronic-phase chronic myeloid leukemia
Chen EY et al. Eur J Haematol, February 2025 – open access publication

Scientific CML papers

CML with mutant ASXL1 showed decreased sensitivity to TKI treatment via upregulation of the ALOX5-BLTR Signaling Pathway
Miyashita N et al. Cancer Sci, February 2025 (epub ahead of print) – open access publication

More CML Publications 2025

Clinical Publications	Scientific Publications
February 2025
Patient-reported outcomes in Chinese patients with chronic myeloid leukemia receiving Olverembatinib: Quality of life matters! Eşkazan AE. Cancer, February 2025	Autophagy and Cancer: Insights into molecular mechanisms and therapeutic approaches for chronic myeloid leukemia – Review Kausar MA et al. Biomolecules, February 2025 – open access publication
Novel treatment strategies for chronic myeloid leukemia – Review Cruz-Rodriguez N and Deininger MW. Blood, February 2025	CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells Guoyun J et al. Exp Hematol, February 2025 – open access publication
Long-term outcomes of tyrosine kinase inhibitors in chronic myeloid leukemia – Review Guilhot F and Hehlmann R. Blood, February 2025	MDM2 inhibitors induce apoptosis by suppressing MDM2 and enhancing p53, Box, Puma and Noxa expression levels in imatinib-resistant chronic myeloid leukemia cells Kimura A et al. Biomed Rep, February 2025 – open access publication
Unrelated bone marrow transplantation for CML after liver transplantation Watanabe M et al. Intern Med, February 2025 (epub ahead of print) – open access publication	MiR-142 deficit in T-cells during blast crisis promotes chronic myeloid leukemia immune escape Chen F et al. Nat Commun, February 2025 – open access publication
Treatment-emergent resistance to asciminib in chronic myeloid leukemia patients due to myristoyl-binding pocket-mutant of BCR::ABL1/A337V can be effectively overcome with dasatinib treatment Batar P et al. Curr Oncol, February 2025 – open access publication	Low-dose bee venom as a potential target against human chronic myeloid leukemia cells Halici H et al. Protein J, February 2025 (epub ahead of print)
A CML patient carrying BCR::ABL1 splicing variant did not experience blast crisis for 15 years without responding to various TKIs Nakamura F et al. Intern Med, February 2025 – open access publication	Circumventing imatinib resistance in chronic myeloid leukemia: Novel Telmirsatan-based cell death modulators with improved activity and stability Gebhart M et al. Eur J Med Chem, February 2025 – open access publication
	Proliferation inhibited by Genipin in human leukemia K562 cells: Involvement of uncoupling protein 2 in mitochondrial damage Zhou Y et al. World J Oncol, February 2025 (epub ahead of print) – open access publication
January 2025
Olverembatinib after failure of tyrosine kinase inhibitors, including ponatinib or asciminib: A phase 1b randomized clinical trial Jabbour E et al. JAMA Oncol, January 2025	Design and fabrication of novel microfluidic-based droplets for drug screening on a chronic myeloid leukemia cell line Jaafari N et al. PLoS, January 2025 – open access publication
Real-world experience in the management of chronic myeloid leukemia patients focused on tyrosine kinase inhibitors intolerance and health-related quality of life Cho HJ et al. Acta Haematol, January 2025 (epub ahead of print)	Exploring the significance of MDM2 gene promotes variants in chronic myeloid leukemia Fontecha MB et al. Leuk Res, January 2025 (epub ahead of print)
Bosutinib for the treatment of CML – using it safely: a Podcast Lipton JH and Cortes JE. Target Oncol, January 2025 (epub ahead of print) – open access publication	N-Degron PROTACs as a potential therapeutic approach for chronic myeloid leukemia Hohmann G & Eldeeb MA. Anticancer Agents Med Chem, January 2025 (epub ahead of print)
The evolution of treatment-free remission Hughes TP et al. Blood, January 2025 (epub ahead of print)	Targeted degradation of SOS1 exhibits potent anticancer activity and overcomes resistance in KRAS-mutant tumors and BCR-ABL positive leukemia Luo Z et al. Cancer Res, January 2025 – open access publication
The recent advance of PROTACs targeting BCR-ABL for the treatment of chronic myeloid leukemia Qian Z et al. Bioorg Chem, January 2025 (epub ahead of print)	Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells Sun X et al. Biochem Pharmacol, January 2025 (epub ahead of print)
Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukemia: Are women and men different? Maduado C et al. ESC Heart Fail, January 2025 (epub ahead of print) – open access publication	Lysosomal acid lipase A modulates leukemia stem cell response to venetoclax/tyrosine kinase inhibitor combination therapy in blast phase chronic myeloid leukemia Minhajuddin M et al. Haematologica, January 2025 – open access publication
Efficacy and safety of the first-in-class STAMP inhibitor asciminib in patients with chronic myeloid leukemia – Review Ureshino H and Kimura S. Clin Lymphoma Myeloma Leuk, January 2025	LIPA-frogging blast phase chronic myeloid leukemia: hopping over resistance with lysosomal targeting Quijada-Alamo M et al. Haematologica, January 2025 – open access publication
Imatinib dose reduction after major molecular response in chronic-phase chronic myeloid leukemia Li Z et al. Cancer, January 2025 – open access publication	Single-cell proteo-transcriptomic profiling reveals altered characteristics of stem and progenitor cells in patients receiving cytoreductive hydroxyurea in early-phase chronic myeloid leukemia Komic H et al. Haematologica, January 2025 – open access publication
Patient-reported outcomes in adults with tyrosine kinase inhibitor-resistant chronic myeloid leukemia receiving olverembatinib Yu L et al. Cancer, January 2025 – open access publication	High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell toxicity in chronic myeloid leukemia Nygren PJ et al. Blood, January 2025 (epub ahead of print)
Favorable transplantation outcome of patients with de novo chronic myeloid leukemia in blast phase (lymphoid and myeloid) Sasaki K. Cancer, January 2025	Tyrosine kinase inhibitor therapy enhances stem cells profile and may contribute to survival of chronic myeloid leukemia stem cells Rocco S et al. J Clin Med, January 2025 – open access publication
Outcomes of pregnancy in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitors Kondo T et al. Cancer, January 2025 – open access publication	EZH2 modulates mRNA splicing and exerts part of its oncogenic function through repression of splicing factors in chronic myeloid leukemia Brunmeier R et al. Leukemia, January 2025 (epub ahead of print) – open access publication
Impact of first- and second-generation tyrosine kinase inhibitors on the development of graft-versus host disease in individuals with CML: A retrospective analysis on behalf of the Polish Adult Leukemia Group Giordano U et al. Biomedicines, January 2025 - open access publication
Clinical and prognostic significance of additional chromosomal abnormalities at diagnosis of chronic myeloid leukemia Mayer J et al. Am J Hematol, January 2025 (epub ahead of print) – open access publication
Sustained treatment-free remission in two chronic myeloid leukemia patients after asciminib discontinuation: a report of two cases Yousefi A et al. Ann Hematol, January 2025 (epub ahead of print) – open access publication
Asciminib versus bosutinib following two or more prior therapies in chronic myeloid leukemia: a plain language summary of the ASCEMBL study Szuber N et al. Future Oncol, January 2025 (epub ahead of print) – open access publication
Discontinuation of tyrosine kinase inhibitor therapy and treatment free remission (TFR) in chronic myeloid leukemia: Successful achievement of TFR in more than two-third of patients in a real-world practice Aleem A et al. Clin Lymphoma Myeloma Leuk, January 2025
Unusually indolent CML: a stable non-responder without complete cytogenetic remission for 30 years including 17 years on TKI therapy Shen Q et al. Leuk Lymphoma, January 2025 (epub ahead of print)