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CML Publications 2018
| Clinical Publications | Scientific Publications |
| December 2018 | |
| Imatinib is still recommended for frontline therapy for CML (Hantel A et al. Blood Adv, December 2018Blood Adv, December 2018) |
A kinase profile-adapted drug combination elicits cooperative effects on leukemia cells carryging BCR-ABL1T315l in PH+ CML (Gleixner KV et al. Leuk Res, December 2018) (epub ahead of print) |
| Management of adverse events associated with bosutinib treatment of chronic-phase chronic myeloid leukemia: expert panel review (Cortes JE et al. J Hematol Oncol, December 2018) |
Predictive models for designing potent tyrosine kinase inhibitors in chronic myeloid leukemia for understanding its molecular mechanism of resistance by molecular docking and dynamics simulations |
| A second-generation TKI should always be used as initial therapy for CML (Cortes JE. Blood Adv, December 2018) |
Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia (Bidet A et al. Haematologica, December 2018) (epub ahead of print) |
| Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV (Michel C et al. Haematologica, December 2018) (epub ahead of print) |
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Nilotinib in the treatment of chronic myeloid leukemia |
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Cardiovascular risk and cardiovascular events in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors |
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| November 2018 | |
| Molecular monitoring in CML: how deep? How often? How should it influence therapy? (Shanmuganathan N et al. Blood, November 2018) |
A modified DAW-22 compound F-B1 inhibits BCR-ABL and induces apoptosis in chronic myelogenous leukemia cells (Wang F et al. Anticancer Drugs, November 2018) (epub ahead of print) |
| Treatment-free remission with first- and second-generation tyrosine kinase inhibitors (Cortes J et al. Am J Hematol, November 2018) |
Genomic amplification of BCR-ABL1 fusion gene and its impact of the disease progression mechanism in patients with chronic myelogenous leukemia (Chandran RK et al. Gene, November 2018) (epub ahead of print) |
| The impact of introducing tyrosine kinase inhibitors on chronic myeloid leukemia survival: a population-based study (Di Felice E et al. BMC Cancer, November 2018) |
To what extent can mathematical modeling inform the design of clinical trials? The example of safe dose reduction of tyrosine kinase inhibitors in responding patients with chronic myeloid leukemia (Schiffer JT et al. Haematologica, November 2018) |
| Back to the future: TFR and pregnancy in CML (Abruzzese E et al. Eur J Haematol, November 2018) (epub ahead of print) |
A new BCR-ABL1 Drosophilia model as a powerful tool to elucidate pathogenesis and progression of chronic myeloid leukemia (Bernardoni R et al. Haematologica, November 2018) (epub ahead of print) |
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Safety and efficacy of bosutinib in fourth-line therapy of chronic myeloid leukemia patients (García-Gutiérrez V et al. Ann Hematol, November 2018)(epub ahead of print) |
Epigenetic regulation of HOTAIR in advanced chronic myeloid leukemia (Li Z et al. Cancer Manag Res, November 2018) |
| Molecular monitoring of therapeutic milestones and clinical outcomes in patients with chronic myeloid leukemia (Klil-Drori AJ et al. Cancer, November 2018) (epub ahead of print) |
Chronic myeloid leukemia with complex karyothypes: Prognosis and therapeutic approaches (Asnafi AA et al. J Cell Physiol, November 2018) (epub ahead of print) |
| October 2018 | |
| Treatment-free remission after second-line nilotinib treatment (Mahon MX et al. Ann Intern Med, October 2018) |
Modeling ponatinib resistance in tyrosine kinase inhibitor naïve and dasatinib resistant BCR-ABL1+ cell lines (Lu L et al. Oncotarget, October 2018) |
| Long-term treatment-free remission of chronic myeloid leukemia with falling levels of residual leukemic cells (Ross DM et al. Leukemia, October, 2018) (epub ahead of print) |
A phase I clinical trial of ruxolitinib in combination with nilotinib in chronic myeloid leukemia patients with molecular evidence of disease (Sweet K et al. Leuk Res, October 2018) (epub ahead of print) |
| Adult leukemia survival trends in the United States by subtype: A population-based registry study of 370,994 patients during 1995-2009 (Bailey C et al. Cancer, October 2018) (epub ahead of print) |
Bone marrow core biopsy in 508 consecutive patients with chronic myeloid leukemia: Assessment of potential value (Hidalgo-López JE et al. Cancer, October 2018) (epub ahead of print) |
| Early molecular response ≤ 1% has strong prognostic impact for CML patients that switch to second line therapy with BCR-ABL ≤ 10% and no major molecular response (Bonecker S et al. Br J Haematol, October 2018) (epub ahead of print) |
Alteration of cellular and immune-related properties of bone marrow mesenchymal stem cells and macrophages by K562 chronic myeloid leukemia cell derived exosomes (Jafarzadeh N et al. J Cell Physiol, October 2018) (epub ahead of print) |
| A prospective analysis of symptom burden for patients with chronic myeloid leukemia in chronic phase treated with frontline second- and third-generation tyrosine kinase inhibitors (Zulbaran-Rojas A et al. Cancer Med, October 2018) (epub ahead of print) |
Optimized digital droplet PCR for BCR-ABL (Maier J et al. J Mol Diagn, October 2018) (epub ahead of print) |
| Treatment-free remission in patients with chronic myeloid leukemia (Rea D et al. Int J Hematol, October 2018) |
Clinical evaluation of massively parallel RNA sequencing for detecting recurrent gene fusion in hematologic malignancies (Kim B et al. J Mol Diagn, October 2018) (epub ahead of print) |
| Tyrosine kinase inhibitor interruptions, discontinuation and switching in patients with chronic-phase chronic myeloid leukemia in routine clinical practice: SIMPLICITY (Hehlmann R et al. Ann J Hematol, October 2018) (epub ahead of print) |
Real-time qualitative PCR: a reliable molecular diagnostic and follow-up tool for ‘minimal residual disease’ assessment in chronic myeloid leukemia (Azad NA et al. Biosci Rep, October 2018) |
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Searching for potential novel BCR-ABL tyrosine kinase inhibitors through G-QSAR and docking studies of some novel 2-phenazinamine derivates |
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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia |
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| September 2018 | |
| Chronic myeloid leukemia relapsing 25 years after allogeneic stem cell transplantation (Reikvam H et al. Case Rep Hematol, September 2018) |
Ponatinib activates an inflammatory response in endothelial cells via ERK5 SUMOylation (Paez-Mayorga J et al. Front Cardiovasc Med, September 2018) |
| Ponatinib evaluation and safety in real-life chronic myelogenous leukemia patients failing more than two tyrosine kinase inhibitors: The PEARL observational study (Heiblig M et al. Exp Hematol, September 2018) (epub ahead of print) |
Autophagy and mitochondrial metabolism: Insights into their role and therapeutic potential for chronic myeloid leukaemia (Baquero J et al. FEBS J, September 2018) (epub ahead of print) |
| Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib (Ottmann O et al. Blood Cancer J, September 2018) |
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal (Toofan P et al. Cell Death Dis, September 2018) |
| Canadian chronic myeloid leukemia outcomes post-transplant in the tyrosine kinase era (Savoie ML. Leuk Res, September 2018) (epub ahead of print) |
Systematic review of pre-clinical chronic myeloid leukemia |
| Identifying tyrosine kinase inhibitor nonadherence in chronic myeloid leukemia: subanalysis of TAKE-IT pilot study (Clin Lymphoma Myeloma Leuk, September 2018) |
CircBA9.3 supports the survival of leukaemic cells by up-regulating C-ABL1 or BCR-ABL1 protein levels (Pan Y et al. Blood Cells Mol Dis, September 2018) (epub ahead of print) |
| Chronic Myeloid Leukemia, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology (Radich JP et al. J Natl. Compr Canc Netw, September 2018) |
Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: involvement of ER stress and DAMP release (Mazumder A et al. Cancer Lett, September 2018) (epub ahead of print) |
| Gene expression analysis of noncoding PCA3 gene in patients with chronic myeloid leukemia (Sajjadi E et al. J Cancer Res Ther, July-September 2018) |
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| August 2018 | |
| Long-term follow-up of de novo chronic phase chronic myelogenous leukemia patients on front-line imatinib (Nicolini FE et al. Exp Hematol, August 2018) |
Development, function and clinical significance of plasmacytoid dentritic cells in chronic myeloid leukemia (Inselmann S et al. Cancer Res, August 2018) (epub ahead of print) |
| Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia (Hughes TH et al. Haematologica, August 2018) (epub ahead of print) |
Consensus of BCR-ABL-1 reporting in chronic myeloid leukemia in the UK (Cross NCP et al. Br J Haematol, August 2018) (epub ahead of print) |
| Impact of earlier versus later monitoring on disease progression and healthcare costs among patients with chronic myeloid leukemia in the United States (Jabbour EJ et al, August 2018) (epub ahead of print) |
The clinical outcomes of chronic myeloid leukemia patients harboring alternatively spliced BCR-ABL variants (Ishida T et al. Hematology, August 2018) (epub ahead of print) |
| Quantitative prediction of long-term molecular response in TKI-treated CML – Lessons from an imatinib versus dasatinib comparison (Glauche I et al. Sci Rep, August 2018) |
Evaluation of resistance to HIV-1 infection ex vivo of PBNCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors (Bermejo M et al. Biochem Pharmacol, August 2018) (epub ahead of print) |
| Outcomes of switching to dasatinib after imatinib-related low-grade adverse events in patients with chronic myeloid leukemia in chronic-phase; the DASPERSE study (Kim DW et al. Ann Hematol, August 2018) |
Crosstalk between BCR-ABL and protease-activated receptor1 (PAR1) suggests a novel target in chronic myeloid leukemia |
| Imatinib through levels: a potential biomarker to predict cytogenetic and molecular response in newly diagnosed patients with chronic myeloid leukemia (Natarajan H et al. Leuk Lymphoma, August 2018) (epub ahead of print) |
Discovery of asciminib (ABL001), an allosteric inhibitor of the tyrosine kinase activity of BCR-ABL-1 |
| July 2018 | |
| Comparison of frequency and sensitivity of BCR-ABL1 kinase domain mutations in Asian and white patients with imatinib-resistant chronic-phase chronic myeloid leukemia (Kim H et al. Clin Lymphoma Myeloma Leuk, July 2018) (epub ahead of print) |
Single-molecule sequencing reveals patterns of pre-existing drug resistance that suggest treatment strategies in Philadelphia-positive leukemias (Schmitt MW et al. Clin Cancer Res, July 2018) (epub ahead of print) |
| Radotinib-induced eruptive melanocytic nevi in patient with chronic myeloid leukemia: a case report and literature review (Park E et al. Ann Hematol, July 2018) (epub ahead of print) |
Insulin resistance is an underlying mechanism of impaired glucose metabolism during nilotinib therapy |
| Chronic myeloid leukemia and pregnancy: patient and partner perspectives (Luskin MR et al. Expert Rev Hematol, July 2018) (epub ahead of print) |
BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia (Pagani IS et al. Haematologica, July 2018) (epub ahead of print) |
| Switches of tyrosine-kinase inhibitors in chronic phase of chronic myeloid leukemia in real life (Am J Hematol, July 2018) (epub ahead of print) |
Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high risk disease (Branford S et al. Blood, July 2018) (epub ahead of print) |
| Extended dose with CC-486 (oral azacitidine) in patients with myloid malignancies (Savona MR et al. Am J Hematol, July 2018) (epub ahead of print) |
Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia (Bouillon AS et al. Blood Adv, July 2018) |
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A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML (Gopal S et al. Blood Adv, July 2018) |
| The underestimated role of basophils in PH+ CML (Valent P et al. Eur J Clin Invest, July 2018) |
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| HDAC inhibitor suppresses proliferation and tumorigenicity of drug-resistant chronic myeloid leukemia stem cells through regulation of has-miR-196a targeting BCR/ABL1 (Bamodu OA et al. Exp Cell Res, July 2018) (epub ahead of print) |
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| CDA gene silencing regulated the proliferation and apoptosis of chronic myeloid leukemia K562 cells (Wei XF et al. Cancer Cell Int, July 2018) |
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| The potential of exosomes derived from chronic myelogenous leukemia cells as a biomarker (Kang KW et al. Anticancer Res, July 2018) |
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| June 2018 | |
| Effect of adherence-enhancing interventions on adherence to tyrosine kinase inhibitor treatment in chronic myeloid leukemia (TAKE-IT): A quasi-experimental pre-post intervention multicenter pilot study (Leader A et al. Clin Lymphoma Myeloma Leuk, June 2018) (epub ahead of print) |
Past, present, and future of BCR-ABL inhibitors: from chemical development to clinical efficacy (Rossari F et al. J Hematol Oncol, June 2018) (Epub ahead of print) |
| The story of tyrosine kinase inhibitors discontinuation in clinical practice (Rousselot P. Leuk Lyphoma, June 2018) (epub ahead of print) |
Novel combined Ato-C treatment synergistically suppresses proliferation of BCR-ABL-positive leukemic cells in vitro and in vivo |
| Clinical results according to age in patients with chronic myeloid leukemia receiving imatinib frontline: the younger, the later, the worse? (Latagliata R et al. Eur J Haematol, June 2018) |
Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML (Brück O et al. Leukemia, June 2018) (epub ahead of print) |
| Upfront low-dose ponatinib (15mg/day) for multi-TKI resistant chronic myeloid leukemia (Tefferi A et al. Hematol Oncol, June 2018) |
Integrated computational biology analysis to evaluate target genes for chronic myelogenous leukemia (Zheng Y et al. Mol Med Rep, June 2018) (epub ahead of print) |
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Present results and future perspectives in optimizing chronic myeloid leukemia therapy |
Chronic myelogenous leukemia on target (Némethová V et al. Cancer Med, June 2018) (epub ahead of print) |
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Beyond maximum grade: modernizing the assessment and reporting of adverse events in haematological malignancies |
SiRNA/Lipopolymer nanoparticles to arrest growth of chronic myeloid leukemia cells in vitro and in vivo (Valencia-Serna J et al. Eur J Pharm Biopharm, June 2018) (epub ahead of print) |
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Comparative analysis of nilotinib versus high-dose imatinib versus sustained standard-dose imatinib in patients with chronic myeloid leukemia following sub-optimal response to first-line imatinib |
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| May 2018 | |
| Management of pregnancy in women with chronic myeloid leukemia (Ross D et al. J Clin Oncol, May 2018) (epub ahead of print) |
Experimental and integrative analyses identify an ETS1 network downstream BCR-ABL in chronic myeloid leukemia (CML) (Desterke C et al. Exp Hematol, May 2018) (epub ahead of print) |
| The evolution of dasatinib dosage over the years and its relevance to other anticancer medications (Schiffer CA et al. Cancer, May 2018) (epub ahead of print) |
Residual peripheral blood CD26+ leukemic stem cells in chronic myeloid leukemia patients during TKI therapy and during treatment-free remission (Bocchia M et al. Front Oncol, May 2018) |
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Long-term follow-up of de novo chronic myelogenous leukemia patients on imatinib first-line |
Targeting BCR-ABL-independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition (Mitchell R et al. J Natl Cancer Inst, May 2018) |
| Early results of lower dose dasatinib (50 mg daily) as frontline therapy for newly diagnosed chronic-phase chronic myeloid leukemia (Naqvi K et al. Cancer, May 2018) (epub ahead of print) |
Bosutinib, dasatinib, imatinib, nilotinib, and ponatinib differentially affect the vascular molecular pathways and functionality of human endothelial cells (Gover-Proaktor A et al. Leuk Lymphoma, May 2018) (epub ahead of print) |
| Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicenter, non-randomised trial (Saussele S et al. Lancet Oncology, May 2018) (epub ahead of print) |
Targeting HSP90 dimerization via the C-terminus is effective in imatinib resistant CML and lacks heat shock response (Bhatia S et al. Blood, May 2018) (epub ahead of print) |
| Reduced-dose imatinib in chronic-phase CML (Das M et al. Lancet Oncol, May 2018) (epub ahead of print) |
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Safety and efficacy of second-line bosutinib for chronic phase chronic myeloid leukemia over a five-year period: final results of a phase 1/2 study |
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Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: Recommendations for clinical practice from the French chronic myeloid leukemia study group |
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Pregnancy in patients with chronic myeloid leukemia |
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Real-life experience with ponatinib in chronic myeloid leukemia: A multicenter observational study |
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Breastfeeding in patients with chronic myeloid leukemia: Case series with measurements of drug concentrations in maternal milk and literature review |
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| April 2018 | |
| Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia (Atallah E et al. BMC Cancer, April 2018) |
Validation of the EUTOS long-term survival score in a recent independent cohort of “real-world” CML patients (Geelen IGP et al. Leukemia, April 2018) |
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Considerations of treatment-free remission in patients with chronic myeloid leukemia: A joint patient-physician perspective |
The benefit of quality control charts (QCC) for routine quantitative BCR-ABL1 monitoring in chronic myeloid leukemia (Spiess B et al. PLoS One, April 2018) |
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Severe adverse events by tyrosine kinase inhibitors decrease survival rates in patients with newly diagnosed chronic phase chronic myeloid leukemia |
Evaluation of the primitive fraction by functional in vitro assays at the RNA and DNA level represents a novel tool for complementing molecular monitoring in chronic myeloid leukemia (Ruiz MS et al. Oncotarget, April 2018) |
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Anxiety and depression associated with tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia |
Differential proteomic profile of leukemic CD34+ progenitor cells from chronic myeloid leukemia patients (Ricciardi MR et al. Oncotarget, April 2018) |
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Ponatinib as second-line treatment in chronic-phase chronic myeloid leukemia patients in real-life practice |
Droplet digital PCR for BCR-ABL (P210) detecting of CML: A high sensitive method of the minimal residual disease and disease progression (Wang WJ et al. Eur J Haematol, April 2018) (epub ahead of print) |
| Aberrant DNA methylation of SOCS1 gene is not associated with resistance to imatinib mesylate among chronic myeloid leukemia patients (Elias MH et al. Cardiovasc Hematol Disord Drug Targets, April 2018) (epub ahead of print) |
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| CD69 partially inhibits apoptosis and erythroid differentiation via CD24, and their knockdown increase imatinib sensitivity in BCR-ABL-positive cells (Huang SY et al. J Cell Physiol, April 2018) |
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Wool-like hollow polymeric nanoparticles for CML chemo-combinatorial therapy |
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| New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time (Tong YQ et al. Leuk Res, April 2018) (epub ahead of print) |
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| March 2018 | |
| Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial (Cortes JE et al. Blood, March 2018) (epub ahead of print) |
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| Health-related quality of life in patients with chronic myeloid leukemia receiving first-line therapy with nilotinib (Efficace F et al. Cancer, March 2018) (epub ahead of print) |
Bone marrow niche trafficking of MiR-126 controls the self-renewal of leukemia cells in chronic myelogenous leukemia (Zhang B et al. Nat Med, March 2018) (epub ahead of print) |
| Prediction of sustained deep molecular response of BCR-ABL1 levels in patients with chronic myeloid leukemia in chronic phase (Sasaki K et al. Cancer, March 2018) |
Patients with low OCT-1 activity and high ABCB1 fold rise have poor long-term outcomes in response to tyrosine kinase inhibitor therapy (Eadie LN et al. Leukemia, March 2018) (epub ahead of print) |
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Safety and efficacy of nilotonib in routine clinical practice with chronic myeloid leukemia in chronic or accelerated phase with resistance or intolerance to imatinib: results from the NOVEL study |
Plasma and intracellular concentrations in an elderly patient with chronic myeloid leukemia receiving low-dose dasatinib therapy (Imamura M et al. Geriatr Gerontol Int, March 2018) |
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Imatinib-induced fulminant liver failure in chronic myeloid leukemia: role of liver transplant and second-generation tyrosine kinase inhibitors: a case report |
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemic cells (Mathew NR et al. Nat Med, March 2018) |
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Novel tyrosine-kinase inhibitors for the treatment of chronic myeloid leukemia: safety and efficacy |
Targeting PFKFB3 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitor |
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When to stop tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia |
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Current information and recommendations on the discontinuation of TKI inhibitors in chronic myeloid leukemia |
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| February 2018 | |
| Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV (Saussele S et al. Leukemia, February 2018) (epub ahead of print) |
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Efficacy and safety of nilotinib 300 mg twice daily in patients with chronic-myeloid leukemia in chronic phase who are intolerant to prior tyrosine kinase inhibitors: Results from the IIIb ENESTswift study |
Characteristics and outcome of chronic myeloid leukemia patients with E255K/V BCR-ABL kinase domain mutations |
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Durable treatment-free remission in patients with chronic myeloid leukemia in chronic phase following frontline nilotinib: 96-week update of the ENESTfreedom study |
Effect of ABCG2, OCT1, and AB1 (MDR1) gene expression on treatment-free remission in a EURO-SKI subtrial (Rinaldetti S et al. Clin Lymphoma Myeloma Leuk, February 2018) (epub ahead of print) |
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The cure of chronic myeloid leukemia: Are we there yet? |
Overexpression of TpK2 is linked to imatinib resistance and activation of MEK-ERK and NF-kB pathways in a model of chronic myeloid leukemia (Chorzalska A et al. Mol Oncol, February 2018) |
| Considerations for successful treatment-free remission in chronic myeloid leukemia (Goldberg SL et al. Clin Lymphoma Myeloma Leuk, February 2018) |
Therapy-free remission in chronic myeloid leukemia: possible mechanisms (Gale RP et al. Expert Rev Hematol, February 2018) |
| Chronic myelogenous leukemia: Pregnancy in the era of stopping tyrosine kinase inhibitor therapy (Berman E et al. J Clin Oncol, February 2018) (epub ahead of print) |
Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy (Soverini S et al. Mol Cancer, February 2018) |
| Identification of chronic myeloid leukemia patients treated with imatinib who are potentially eligible for treatment discontinuation by assessing real-life molecular response on the international scale in a EUTOS-certified lab (Heinrichs A et al. Leuk Res, February 2018) (epub ahead of print) |
Has-mir183/EGF-1 mediated regulation of E2F1 is required for CML stem/progenitor cell survival (Pellicano F et al. Blood, February 2018) (epub ahead of print) |
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An observational study on risk of secondary cancers in chronic myeloid leukemia patients in the TKI era in the United States |
Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia |
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Cardiovascular, pulmonary, and metabolic toxicities complicating tyrosine kinase inhibitor therapy in chronic myeloid leukemia: Strategies for monitoring, detecting, and managing |
Non ABL-directed inhibitors as alternative treatment strategies for chronic myeloid leukemia |
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Efficacy and safety of nilotinib therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase |
Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis
(Cargnin S et al. Pharmacol Res, February 2018) |
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Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chroni myeloid leukemia |
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| January 2018 | |
| Dasatinib dose management for the treatment of chronic myeloid leukemia (Talpaz M et al. Cancer, January 2018) (epub ahead of print) |
Prognostic significance of additional chromosomal abnormalities at the time of diagnosis in patients with chronic myeloid leukemia treated with frontline tyrosine kinase inhibitors (Alhuraiji A et al. Am J Hematol, January 2018) |
| Dasatinib-induced pulmonary arterial hypertension – A rare late complication (Ibrahim U et al. J Oncol Pharm Pract, January 2018) (epub ahead of print) |
Monitoring of leukemia stem cells in chronic myeloid leukemia patients (Cui J et al. Leuk Lymphoma, January 2018) (epub ahead of print) |
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Dasatinib-induced pulmonary arterial hypertension |
Altered intracellular signaling by imatinb increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells (Hirao T et al. Cancer Sci, January 2018) |
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Will tyrosine kinase inhibitors be part of the treatment armamentarium for CML in the future? |
Lithium, a classic drug in psychiatry, improves nilotinib-mediated antileukemic effects |
| Monitoring TKI therapeutic responses with the panel of metabolic biomarkers in the chronic myeloid leukemia patients (Yang B et al. Cancer Sci, January 2018) (epub ahead of print) |
Dual drug targeting of mutant BCR-ABL induces inactive confirmation: |
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Racial differences in four leukemia subtypes: Comprehensive descriptive epidemiology |
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Antitumor effects of blocking protein neddylation in T3151-BCR-ABL leukemia cells and leukemia stem cells |
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Blockage of endoplasmic reticulum attenuates nilotinib-induces cardiotoxicity by inhibition of the Akt-GSK3ß-Nox4 signaling |
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Effects on antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells |
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| Therapeutic targeting of CK2 in acute and chronic leukemias (Buontempo F et al. Leukemia, January 2018) |
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| December 2017 | |
| Treatment-free remission in CML: who, how, and why? (Mahon FX. Hematology Am Soc Hematol Educ Program, December 2017) |
Exosomes derived from imatinib-resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug-resistant trait by delivering miR-365 (Min QH et al. Exp Cell Res, December 2017) (epub ahead of print) |
| Cardiovascular care of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) therapy (Barber MC et al. Hematology Am Soc Hematol Educ Program, December 2017) |
Ecotopic viral integration site 1 (EVL1) transcriptionally targets talin 1 (TLN1) and upregulates its expression in chronic myeloid leukemia (Halder A et al. Leuk Lymphoma, December 2017) (epub ahead of print) |
| Novel approaches to therapy in CML (Bhatia R et al. Hematology Am Soc Hematol Educ Program, December 2017) |
C1206, a novel curcumin derivate, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro (Fan YL et al. Acta Pharmacol, December 2017) (epub ahead of print) |
| Front-line treatment options for chronic-phase chronic myeloid leukemia (Shah NP et al. J Clin Oncol, December 2017) (epub ahead of print) |
Monocytic myeloid-derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib (Giallongo C et al. J Cell Mol Med, December 2017) (epub ahead of print) |
| Mechanisms of resistance to targeted therapies in chronic myeloid leukemia (Lussana F et al. Handb Exp Pharmacol, December 2017) (epub ahead of print) |
Controversies regarding use of myeloid growth factors in leukemia (Poston JN et al. J Natl Compr Canc Netw, December 2017) |
| Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapharesis appropriate? A case report and review of the literature (Staley EM et al. Transfusion, December 2017) (epub ahead of print) |
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Atypcial chronic myeloid leukemia: a rare entity with management challenges (Dhakal P et al. Future Oncol, December 2017)(epub ahead of print) |
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Successful ovarian stimulation for fertility preservation in a patient with chronic myeloid leukemia: switch from nilotinib to interferon-alpha |
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CML Publications 2014-2017
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iCMLf Conversations on CML and COVID-19 - Recordings available to view
The iCMLf is hosting conversations on CML and COVID-19 with renowed experts in CML that address key questions on how to manage patients with CML during the COVID-19 pandemic. You can view recordings of the conversations here. The content of the presentations express the individual opinions of the respective experts.
An Expert Opinion: Interferon and CML during the COVID-19 Pandemic
Over the last few days, reports of the possible efficacy of interferon in treating COVID have emerged.1,2 This needs some clarity for CML patients as there are different interferons.
With a long standing history of treating CML with interferon, the question has been raised as to whether patients on interferon have more resistance to COVID and even if patients are on tyrosine kinase therapy, should we be switching them to interferon. As can be seen at other places on the iCMLf website, it is not at all clear that CML patients are more at risk for COVID than the general population or whether they will have worse outcome infections if they do get the viral infection.
Secondly, as is reviewed in the papers by Talpaz et al and Cayssials et al, alpha-interferon is active against CML either alone or in combination.3,4 This is a different drug than the beta-interferon used in the Lancet studies quoted above.1,2 Beta-interferon has no significant activity against CML. The most common use of beta-interferon has been in the therapy of multiple sclerosis. Gamma-interferon, which showed some activity against CML, has never really been put into clinical use for any disease.
A paper by Almeida et al, actually describes two MS patients who developed CML while on therapy with beta-interferon.5
In a review by Ahsan et al on the possible therapy for COVID19, a number of drugs have been discussed.6 The use of inhaled alpha-interferon in prophylaxis of corona viruses has been discussed. The idea of using this application to prevent respiratory viruses was abandoned decades ago because of convenience and cost.
In summary, the beta-interferon work in the therapy of COVID-19 needs additional study but is tantalizing. By no means however, should CML patients consider interferon as an option to replace TKI therapy other than very limited indications, such as combination therapy studies, TKI intolerance or pregnancy and then only under the strict guidance of a knowledgeable physician experienced with the use of alpha-interferon.
Professor Jeff Lipton
Princess Margaret Hospital
Toronto, Canada
References
- Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomized, phase 2 trial. Hung IF, et al Lancet. 2020 May 8. pii: S0140-6736(20)31042-4. doi: 10.1016/S0140-6736(20)31042-4. [Epub ahead of print]
- Interferon beta-1b for COVID-19. Shalhoub S. Lancet. 2020 May 8. pii: S0140-6736(20)31101-6. doi: 10.1016/S0140-6736(20)31101-6. [Epub ahead of print] No abstract available.
- The interferon-alpha revival in CML. Talpaz M, Mercer J, Hehlmann R. Ann Hematol. 2015 Apr;94 Suppl 2:S195-207. doi: 10.1007/s00277-015-2326-y. Epub 2015 Mar 27. Review
- Beyond tyrosine kinase inhibitors: Combinations and other agents. Cayssials E, Guilhot F. Best Pract Res Clin Haematol. 2016 Sep;29(3):271-283. doi: 10.1016/j.beha.2016.10.017. Epub 2016 Oct 20. Review.
- Chronic myeloid leukaemia in two multiple sclerosis patients on interferon beta-1a. Almeida L, Neves M, Cardoso E, Melo A. J Clin Pharm Ther. 2009 Feb;34(1):125-7. doi: 10.1111/j.1365-2710.2008.00983.x.
- Treatment of SARS-CoV-2: How far have we reached? Ahsan W, Javed S, Bratty MA, Alhazmi HA, Najmi A. Drug Discov Ther. 2020 May 6;14(2):67-72. doi: 10.5582/ddt.2020.03008. Epub 2020 Apr 25. Review.
More papers on COVID-19
April 2020
- Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory diseases syndrome in Korea
Ahn JY et al. J Korean Med Sci, April 2020 - open access publication - Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Xu Y et al. Nat Med, April 2020 - open access publication
March 2020
- COVID-19 and the cardiovascular system
Zheng YY et al. Nat Rev Cardiol, March 2020 (epub ahead of print) - open access publication - Challenges of coronavirus disease 2019
Lancet Infect Dis, March 2020 - open access publication
February 2020
- Clinical characteristics of coronavirus disease 2019 in China
Guan W et al. N Eng J Med, February 2020 - open access publication - Q&A: The novel coronavirus outbreak causing COVID-19
Fisher D & Heymann D et al. BMC Medicine, February 2020 - open access publication - Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies
Ahmed SF et al. Viruses, February 2020 - open access publication - Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang C et al. Lancet, February 2020 - open access publication - Update: Public health responses to the coronavirus disease 2019 outbreak - United States, February 24, 2020
Jernigan DB & CDC COVID-19 Response Team, MMWR Morb Mortal Wkly Rep, February 2020
- open access publication - Coronavirus disease 2019 (COVID-19) and pregnancy: What obstetricians need to know
Rasmussen SA et al. Obstet Gynecol, February 2020 (epub ahead of publication) - open access publication - The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) - China, 2020
The novel Coronavirus Pneumonia Emergency Response Epidemiology Team, Center of Disease Control (CDC) China Weekly
Publications on COVID-19 and CML - 2020
Papers on COVID-19 and CML/cancer - 2020
December 2020
- Tyrosine kinase inhibitors and COVID-19
Semih B et al. J Oncol Pharm Pract, December 2020 - Outcomes of patients with haematological malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub
Wood WA et al. Blood Adv, December 2020 – open access publication - The management of hematologic malignancies during the COVID-19 pandemic
Hus I et al. Expert Opin Pharmacother, December 2020 (epub ahead of print) - Effect of age, comorbidity and remission status on outcome of COVID-19 in patients with haematological malignancies
Borah P et al. Blood Cell Mol Dis, December 2020 (epub ahead of print) - open access publication - How we have protected our patients: The Italian pediatric onco-hematology unit’s response to the COVID-19 pandemic
Amicucci M et al. Pediatr Blood Cancer, December 2020 – open access publication
November 2020
- Outcome of hospitalized patients with haematological malignancies and COVID-19 infection in a large urban healthcare trust in the UK
Garnett C et al. Leuk Lymphoma, November 2020 (epub ahead of print) - High mortality among hospital-acquired COVID-19 infection in patients with cancer: A multicentre observational cohort study
Elkrief A et al. Eur J Cancer, November 2020 – open access publication - COVID-19 severity and outcomes in patients with cancer: A matched cohort study
Brar G et al. J Clin Oncol, November 2020
October 2020
- Impact of hematologic malignancies and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study
García-Suárez J et al. J Hematol Oncol, October 2020 – open access publication - An online tool for predicting the prognosis of cancer patients with SARS-CoV2 infection: a multi-centre study
Song C et al. J Cancer Res Clin Oncol, October 2020 – open access publication - Cancer and COVID-19
Malek AE et al. Lancet Oncol, October 2020 – open access publication - Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert consensus
Currigliano G et al. Ann Oncol, October 2020 - open access publication
September 2020
- Clinical characteristics and risk factors for mortality in hematologic patients affected by COVID-19
Cattaneo C et al. Cancer, September 2020 (epub ahead of print)
– open access publication - Clinical characteristics and outcome of SARS-CoV-2-infected patients with haematological diseases: a retrospective case study in four hospitals in Italy, Spain and The Netherland
Van Doesum J et al. Leukemia, September 2020 – open access publication
August 2020
- Risk factors and outcome of COVID-19 in patients with haematological malignancies
Piñana JL et al. Exp Hematol Oncol, August 2020 – open access publication - COVID-19 in haematological malignancy patients: A protocol for a systemic review and meta-analysis
Chen C et al. Medicine (Baltimore), August 2020 – open access publication - COVID-19 in children with blood and cancer disorders: What do we know so far?
Yadar SP. J Pediatr Hematol Oncol, August 2020 - Outcome of COVID-19 in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors
Basci S et al. J Oncol Pharm Pract, August 2020 - COVID-19 in patients with haematological malignancies: A retrospective case series
Infante MS et al. Int J Lab Hematol, August 2020 (epub ahead of print)
– open access publication - The outcome of COVID-19 in patients with haematological malignancy
Yigenoglu TN et al. J Med Virol, August 2020 (epub ahead of print)
– open access publication - Clinical characteristics and risk factors associated with COVID-10 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
Passamonti F et al. Lancet Haematol, August 2020 (epub ahead of print)
– open access publication - Clinical characteristics, therapeutic management, and prognostic factors of adult COVID-10 inpatients with haematological malignancies
Wu Y et al. Leuk Lymphoma, August 2020 (epub ahead of print)
July 2020
- SARS CoV2 infection in chronic myelogenous leukemia: Severe haematological presentation
Sorà F et al. Transfus Apher Sci, July 2020 (epub ahead of print)
– open access publication - Prevalence of COVID-19 diagnosis in Dutch CML patients during the 2020 SARS-CoV2 pandemic: A prospective cohort study
Ector GICG et al. Leukemia, July 2020 (epub ahead of print)
- open access publication - Survival study of hospitalized patients with concurrent COVID-19 and haematological malignancies
Martín-Moro F et al. Br J Haematol, July 2020 – open access publication - Clinical course and risk factors for mortality from COVID-19 in patients with haematological malignancies
Sanchez-Pina JM et al. Eur J Haematol, July 2020 (epub ahead of print) - COVID-19 in post transplant patients – report of 2 cases
Huang J et al. Am J Transplant, July 2020 – open access publication
June 2020
- Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King’s College Hospital experience
Shah V et al. Br J Haematol, June 2020 (epub ahead of print)
– open access publication - Haematological cancers and risk of severe COVID-19: Exploration and critical evaluation of the evidence to date
El-Sharkawi D et al. Br J Haematol, June 2020 (epub ahead of print)
- open access publication - Chronic myeloid leukemia management at the time of the COVID-19 pandemic in Italy. A campus CML survey
Breccia M et al. Leukemia, June 2020 (epub ahead of print) - open access publication - Interleukin-6 blockade treatment for COVID-19 associated cytokine release syndrome in a patient with poorly controlled chronic myeloid leukemia
Ranger A et al. Br J Haematol, June 2020 (epub ahead of print) - open access publication - Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structural summary of a study protocol for a randomized controlled trial
Allahyari A et al. Trials, June 2020 – open access publication - COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study
Lee LYW et al. Lancet, June 2020 – open access publication - Managing hematology and oncology patients during the COVID-19 pandemic: Interim consensus guidance
Weinkove R et al. Med J Aust, June 2020 – open access publication - Janus faced course of COVID-10 infection in patients with hematological malignancies
Bellmann-Weiler R et al. Eur J Haematol, June 2020 – open access publication - Managing patients with hematological malignancies during COVID-19 pandemic
Sahu KK and Cerny J. Expert Rev Hematol, June 2020 (epub ahead of print) - Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis
Meng Y et al. Version 2. J Hematol Oncol, June 2020 – open access publication - A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: An international Collaborative Group
Al-Shamsi HO et al. Oncologist, June 2020 – open access publication
May 2020
- Frequently asked questions regarding SARS-CoV-2 in cancer patients – recommendations for clinicians caring for patient with malignant diseases
von Lilienfeld-Toal M et al. Leukemia, May 2020 (epub ahead of print)
- open access publication - Two false-negative test results in a symptomatic patient with a confirmed case of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and suspected Stevens-Johnson Syndrome / toxic epidermal necrolysis (SJS/TEN)
Langziel T et al. Cureus, May 2020 – open access publication - COVID-19 in persons with chronic myeloid leukaemia
Li W et al. Leukemia, May 2020 (epub ahead of print) - open access publication - COVID-19 and cancer: A comprehensive review
Gosain R et al. Curr Oncol Rep, May 2020 - open access publication - SARS-CoV-2 (COVID-19) and chronic myeloid leukemia (CML): a Case Report and Review of ABL kinase involvement in viral infection
Abruzzese E et al. Mediterr J Hematol Infect Dis, May 2020 - open access publication - Chronic myeloid leukaemia and the use of tyrosine kinase inhibitors in the days of COVID-19 pandemic
Eskazan AE et al. Br J Clin Pharmacol, May 2020 (epub ahead of print) - open access publication - Treating leukemia in the time of COVID-19
Paul S et al. Acta Haematol, May 2020 (epub ahead of print) - open access publication - The CoV-2 outbreak: how hematologists could help to fight COVID-19
Galimberti S et al. Pharmacol Res, May 2020 (epub ahead of print) - open access publications - Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomized, phase 2 trial
Hung IF et al. The Lancet, May 2020 – open access publication - Successful prevention and screening strategies for COVID-19: focused on patients with hematological diseases
Cho SY et al. Br J Haematol, May 2020 - open access publication
April 2020
- Hematology in the time of COVID-19
Gavillet M et al. Rev Med Suisse, April 2020 (in French) - COVID-19 in persons with hematological cancers
He W et al. Leukemia, April 2020 (epub ahead of print) - Effect of the COVID-19 pandemic on cancer treatment and research
Saini KS et al. Lancet Haematol, April 2020 (epub ahead of print) - What the oncologist needs to learn about COVID-19 infection in cancer patients
Rassy E et al. Future Oncol, April 2020 (epub ahead of print) - open access publication
March 2020
- The first report of the prevalence of COVID-19 in chronic myelogenous leukemia patients in the core epidemic area of China: multicentre, cross-sectional survey
Wang DY et al. MedRxix, March 2020 (epub ahead of print) - open access publication - Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China
Liang W et al. Lancet Oncol, March 2020 - open access publication - Coronavirus disease COVID-19: EBMT recommendations update March 23, 2020
European Society for Blood and Marrow Transplantation (EBMT), March 2020 - open access publication
March 2018
- Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors
Journal of General Virology 2018;99:619–630 - open access publication
Papers on COVID-19
-
April 2020
- Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory diseases syndrome in Korea
Ahn JY et al. J Korean Med Sci, April 2020 - open access publication - Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Xu Y et al. Nat Med, April 2020 - open access publication
March 2020
- COVID-19 and the cardiovascular system
Zheng YY et al. Nat Rev Cardiol, March 2020 (epub ahead of print) - open access publication - Challenges of coronavirus disease 2019
Lancet Infect Dis, March 2020 - open access publication
February 2020
- Clinical characteristics of coronavirus disease 2019 in China
Guan W et al. N Eng J Med, February 2020 - open access publication - Q&A: The novel coronavirus outbreak causing COVID-19
Fisher D & Heymann D et al. BMC Medicine, February 2020 - open access publication - Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies
Ahmed SF et al. Viruses, February 2020 - open access publication - Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang C et al. Lancet, February 2020 - open access publication - Update: Public health responses to the coronavirus disease 2019 outbreak - United States, February 24, 2020
Jernigan DB & CDC COVID-19 Response Team, MMWR Morb Mortal Wkly Rep, February 2020
- open access publication - Coronavirus disease 2019 (COVID-19) and pregnancy: What obstetricians need to know
Rasmussen SA et al. Obstet Gynecol, February 2020 (epub ahead of publication) - open access publication - The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) - China, 2020
The novel Coronavirus Pneumonia Emergency Response Epidemiology Team, Center of Disease Control (CDC) China Weekly
- Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory diseases syndrome in Korea
Advice for people with chronic myeloid leukemia on COVID-19
The iCMLf is sharing an expert statement specifically for chronic phase CML patients on the novel coronavirus and the COVID-19 disease.
