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Giora Sharf - Can we safely stop TKI therapies? Experience from the STOP trials (2)

Non-adherence of CML patients

Results of the global adherence survey of the CML Advocates Network
Giora Sharf, CML Advocates Network

 

Issues covered:

  • Results of the global adherence survey of 2546 CML patients from 79 countries
  • Intentional and non-intentional non-adherence levels
  • Differences between countries, type of TKI, administration schedule, age groups, perception of quality of life and side effects
  • Tools to drive adherence and importance of routine

 

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Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

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Jorge Cortes - New Drugs in the Treatment of CML

New Drugs in the Treatment of CML

Jorge Cortes, MD Anderson Cancer Center, USA

Please click on the image below to watch the webcast, and a window will open. You can then also click on the slides to jump to certain sections of the presentation. Please share your feedback below, and view the other Virtual Education Program modules.

 

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edut-cortes 260

 

Issues covered

  • Unmet medical needs in currently available CML treatments
  • Treatment options for CML with T315I mutation
  • Treatment options after TKI intolerance
  • Trial results with bosutinib, ponatinib, omacetaxine
  • Results from studies investigating imatinib + interferon

Has this been helpful? Please provide your comments here:

Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

Delphine Rea - Can we safely stop TKI therapies? Experience from the STOP trials

Can we safely stop TKI therapies? Experience from the STOP trials

Delphine Rea, Hôpital Saint-Louis, Paris, France

Please wait as the educational presentation will start automatically. You can also click on the slides to jump to certain sections of the presentation. Please share your feedback below, and view the other Virtual Education Program modules.

 

webcast-button
delphine-rea

 

Issues covered

  • Unmet medical needs in currently available CML treatments
  • Treatment options for CML with T315I mutation
  • Treatment options after TKI intolerance
  • Trial results with bosutinib, ponatinib, omacetaxine
  • Results from studies investigating imatinib + interferon

Has this been helpful? Please provide your comments here:

Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

Jerry Radich - Transplantation for CML in 2011: Who, why, when?

Transplantation for CML in 2011: Who, why, when?

Jerry Radich, Fred Hutchinson Cancer Research Center, Seattle, USA

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vep jerryradich

 

Issues covered

  • The role of transplantation in 2011
  • Who should be transplanted
  • When they should be transplanted
  • Why they should be transplanted

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Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

Susan Branford - The importance of BCR-ABL kinase domain mutation analysis in CML

The importance of BCR-ABL kinase domain
mutation analysis in CML

Susan Branford, University of Adelaide, Australia

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vep branford mutationanalysis

 

Issues covered

  • Mutations as a mechanism of imatinib resistance
  • Why mutations arise
  • When to test for mutations
  • Therapeutic options in the presence of mutations

 

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Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

Susan Branford - the importance of Molecular Monitoring in CML

The importance of Molecular Monitoring in CML

Susan Branford, University of Adelaide, Australia

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vep branford molecmonitoring

 

Issues covered

  • Measurement of BCR-ABL transcript levels to assess residual disease
  • Recommended monitoring for CML
  • The significance of achieving a major molecular response

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Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

John Goldman: CML Treatment with imatinib

John Goldman: CML Treatment with imatinib

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iv-goldman

Issues covered in this presentation:

  • Biology and mechanisms of CML
  • Mechanism of action of imatinib
  • Results of the IRIS study
  • Adverse effects of imatinib
  • Methods to detect residual disease
  • Imatinib in children and in pregnancy
  

 

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Michele Baccarani - European Leukemia Network (ELN) recommendations

Michele Baccarani - European Leukemia Network (ELN) recommendations

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iv-baccarani

Issues covered in this presentation:

  • Predicting response to imatinib
  • Depth of response, does it matter?
  • Primary and secondary failure to imatinib
  • How to monitor response
  • Treatment recommendations

 

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Timothy Hughes - Optimising response and managing resistance to treatment

Please click on the image below to watch the webcast, and a window will open. You can then also click on the slides to jump to certain sections of the presentation. We appreciate your feedback: Please rate the video with the radio buttons above, share your comments using comments box below, or share your ideas in our Discussion Forum. View the other Virtual Education Program modules.

 

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iv-hughes

 

Issues covered in this presentation:

  • Definition of optimal response to imatinib
  • Suboptimal response
  • Considerations for managing suboptimal response, case study
  • Adherence and molecular response
  • Role of mutations, criteria for mutation screening on first line therapy
  • Dose related toxicities with TKI’s; concomitant medications

 

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Jorge Cortes - Treatment of patients after imatinib first line therapy

Jorge Cortes - Treatment of patients after imatinib first line therapy

Please click on the video to start the presentation. While watching the presentation, you can also click on each of the small slides to jump to the sections. We appreciate your feedback: Please rate the video with the radio buttons above, share your comments using comments box below, or share your ideas in our Discussion Forum. View the other Virtual Education Program modules.

 

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iv-cortes

 

Issues covered in this presentation:

  • Survival post imatinib
  • Treatment with 2nd generation TKIs (2nd line, 1st line)
  • Optimal time to switch therapy
  • Strategies to prevent imatinib failure
  • Role of interferon and transplantation
  • Presentation of new agents under investigation

 

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