The iCMLf commenced our 2024 regional program this week, hosting the first session of the South Asian Regional Discussion Group. Aimed at addressing localised challenges in treating CML, the session brought together physicians from across South Asia to engage in discussions and share case examples. Initially launched in 2023, the Regional Discussion Group program is designed to provide a platform for physicians across low- and middle-income countries to interact with both international and regional CML experts.

TKI choice and sequencing of treatment in a world of increasing options

The first topic, ‘TKI choice and sequencing of treatment in a world of increasing options’ was presented by Dr Tulika Seth from New Delhi, India, and Professor Gianantonio Rosti from Meldola (FC), Italy. Dr. Seth presented two cases, addressing the challenges ‘Choice of first line therapy, what to look for in your first TKI’, with the case of a 35-year-old female patient, newly diagnosed CML-CP. This was followed with the case of a 55-year-old male and the failure of frontline second generation TKI, with the challenge ‘If no mutation – how to choose second line’? Led by Dr Rosti, attendees engaged in a robust discussion on the optimal selection and sequencing of TKIs for these patients, not only addressing current practices but also exploring emerging trends and future considerations, with a particular focus on factors specific to South Asian patients. 

Anticipating and managing acute TKI toxicity and adverse events

Following a lively discussion of the cases, the session moved onto the second topic, ‘Anticipating and managing acute TKI toxicity and adverse events’, presented by Professor Hemant Malhotra from Jaipur, India and Dr Massimo Breccia from Rome, Italy. Participants shared insights and strategies for anticipating and managing acute toxicities effectively. Dr. Malhotra compared the differing properties of TKIs and the relevant toxicities and dose schedules, before presenting the case of a 44-year-old farmer with Tumor Lysis Syndrome. In his second case, he discussed a 37-year-old policewoman and the approach taken to dasatinib-induced pleural effusion. Led by Dr Breccia, a lively discussion from participants concluded that an integrated approach is needed for best outcomes.

We thank Dr Seth and Professor Malhotra for these case examples which provided a practical context, fostering a collaborative approach towards enhancing patient care.

The session served as a platform for fruitful discussions and knowledge sharing, marking a positive beginning to the series of Regional Discussion Groups planned for the year, addressing localised challenges and evidencing the supportive network within the CML community. We are particularly grateful not only to our hosts, for their preparation and contributions, and also to everyone who attended and participated.

Highlights from the session will be available soon. You can sign up for Meetings 2 and 3 here.

Keep a look out for Latin America and Africa Regional Discussion Groups coming later this year.

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We look forward to seeing you there.